Korea develops technology to reverse skin cell aging

mymedicplus — Sat, 28 Nov 2020 06:19:15 +0000

Source – https://www.biospectrumasia.com/

The team found the potential to reverse the biological phenomenon of aging in skin cells through PDK1 inhibition model

Amorepacific R&D Center, together with the Korea Advanced Institute of Science & Technology (KAIST), developed an original technology that reverses the aging process in human dermal fibroblasts. The system’s biology research was conducted in collaboration with a research team led by Professor Cho Kwang-hyun of the Department of Bio and Brain Engineering at KAIST. The result of the research was published in the online edition of an internationally renowned scientific journal, PNAS, on November 23. (The research article is titled “Inhibition of 3-phosphoinositide–dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts”.)

In this industry-university research collaboration, Amorepacific R&D Center and Professor Cho’s team developed a signaling network model for aging skin cells. The joint team ran simulations to analyze the model and discovered a core f that reverses aging in old cells and converts them into younger cells. Using this factor, the team managed to develop an original technology for reverse aging.

These findings are meaningful in that we have found the potential to reverse the biological phenomenon of aging in skin cells that was previously considered irreversible. When we regulated the activity of PDK1 (3-phosphoinositide–dependent protein kinase 1), the core factor that reverse aging, in the artificial model of aged skin, we found that PDK1 inhibition not only reverses the reduction in collagen synthesis, but also helps recover the skin’s ability to regenerate. It is expected that we can leverage this reverse aging technology to not only predict and suppress the progress of age-related diseases, but also to prolong the healthy years of our lives.

Park Won-seok, Director of Research & Innovation Center at Amorepacific R&D Center said, “The joint research enabled us to build an aging signal network model and an artificial model for aged skin, with which we saw the potential to reverse the aging process in the skin.”

Based on the results of the studies, Amorepacific R&D Center is developing cosmetics that reduce wrinkles by extracting a core ingredient in Camellia japonica seed extract that controls aging in human skin.

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IIT develops low-cost tech to produce psychoactive drugs, anti-aging compounds from agri resources

mymedicplus — Wed, 28 Oct 2020 06:02:41 +0000

Source – https://www.hindustantimes.com/

The technology which has been patented and developed by Mihir Kumar Purkait, Head, Centre for the Environment and Professor, Department of Chemical Engineering, IIT Guwahati along with his M Tech student V L Dhadge, does not use any organic solvents.

Researchers at the Indian Institute of Technology (IIT), Guwahati, have developed a low-cost membrane technology to produce psychoactive drugs and anti-aging compounds from wide range of agricultural resources like citrus fruits and peels especially orange peels, berries, parsley, pulses, tea, sea buckthorn and onions.

The technology which has been patented and developed by Mihir Kumar Purkait, Head, Centre for the Environment and Professor, Department of Chemical Engineering, IIT Guwahati along with his M Tech student V L Dhadge, does not use any organic solvents.

“The health-related beneﬁts of psychoactive drugs (caffeine) and anti-aging compounds (ﬂavonoids) attributed to stimulating detoxiﬁcation of enzyme activity and inhibition of cell invasion and angiogenesis. Because of medicinal applications, ﬂavonoid components have gained popularity as ingredients in pharmaceutical industry. These are also found in smaller amount in bamboo leaves, grapes, apples, and other natural sources,” said Purkait.

“The developed technology is exclusively pore and particle size based pressure driven membrane separation process. The water extracts of the plants, fruits or leaves at optimum operating conditions are passed through a specially made cascade membrane units of fabricated with appropriate molecular weight cut off (MWCO) membranes capable of separating targeted flavonoids selectively,” he added.

The permeate and retentive part from appropriate membrane unit is then fridge dried to get the powdered product. “We have synthesized stimuli responsive smart membrane for the selective separation and purification of targeted compound from the mixture of plants or leaves or fruits extract in simple water,” he further said.

The professor explained that the commercially available techniques are using various costly organic solvents like Chloroform, Acetone, Acetonitrile, among others and as a result the price of these important pharmaceutical raw materials are quite high that ultimately increases the price of the antioxidant. “Since organic solvents are used, the technology suffers various disadvantages like low product quality and yield, high operating and product cost, more time consuming and high energy intensive process for solvent recovery and has limitation to run continuation mode in industrial scale. “The technology developed by us doesn’t require any costly organic solvents and uses only water. Hence, the cost of the process and price of pharmaceuticals thereon is much cheaper than that of existing solvent based separation technique. The patented membrane based green technology has enormous scope to replace existing costly organic solvent based techniques and can be used for continuation mode of operation in industrial scale,” he said.

The post IIT develops low-cost tech to produce psychoactive drugs, anti-aging compounds from agri resources appeared first on MyMedicPlus.

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Korea develops technology to reverse skin cell aging

IIT develops low-cost tech to produce psychoactive drugs, anti-aging compounds from agri resources

The technology which has been patented and developed by Mihir Kumar Purkait, Head, Centre for the Environment and Professor, Department of Chemical Engineering, IIT Guwahati along with his M Tech student V L Dhadge, does not use any organic solvents.