Researchers from the Mayo Clinic have identified a microbiome signature associated with endometrial cancer, according to a study published in Scientific Reports.¹

The signature is in part driven by postmenopausal status, along with additional known risk factors for endometrial cancer such as obesity and high vaginal pH (>4.5), which together significantly modify the composition of the reproductive tract biome and leads to an increased diversity. Previous studies have demonstrated that healthy vaginal microbiota is most commonly low in diversity and dominated by Lactobacillispecies.

“Of the 17 taxa we found enriched in (endometrial cancer) patients, 8 were also enriched by postmenopause,” said the researchers. “Because postmenopausal status is a main risk factor for endometrial cancer, this system can be thought of as an ecological succession towards a disease state.”

The researchers collected microbiome samples from 148 women undergoing a hysterectomy for either endometrial cancer (n = 66) or other benign uterine conditions (n = 75). The samples were analyzed for diversity across multiple parameters identified as known risks for endometrial cancer. In the lower reproductive tract, both α- and β-diversity were associated with patient menopause status (P = 0.002 and P = 0.007, respectively). In the uterus, the microbiome α-diversity reached significance (P = 0.024), while β-diversity did not (P = 0.221).

“All parameters analyzed (menopause status, BMI, and vaginal pH) showed a significant impact on the microbiome composition, with postmenopause, obesity, and high vaginal pH significantly increasing the microbiome diversity,” noted the researchers. “Of note was the marked enrichment of Anaerococcus, Peptoniphilus, andPorphyromonas species.”

The analysis identified P. somerae as the microbe with the strongest association with endometrial cancer (P < 0.001), which was present in all patients with type II disease and in 57% of those with hyperplasia.

“We know other cancers (cervical, gastric cancers) are associated with certain infections (HPV and H. Pylori, respectively,) so it is intriguing to think that there may be micro-organisms associated with the development of other cancers such as endometrial cancer,” commented Elizabeth Etkin-Kramer, MD, FACOG, assistant professor of gynecology at Florida International University, Herbert Wertheim School of Medicine, who was not involved in the study.

In addition to the small sample size and lack of diversification of those samples, a noted limitation of the study was the poor overall health of the patients without endometrial cancer. 

“These hysterectomy patients came to Mayo Clinic due to abnormal bleeding, pain, or some combination of these,” wrote the researchers. “These were not healthy women.”

Still, the suggested association of a specific microbiome signature for endometrial cancer is enough to warrant further research – with the long-term goal of possibly developing a screening test for the disease.

“If the micriobiome does play a role in endometrial cancer, beyond being a marker for it, this could have important implications for endometrial cancer prevention,” said Maria Walther-Antonio, PhD, of the Miocrobiome Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, in a press release.²

“We need larger studies to further confirm an association of certain microorganisms in women with endometrial cancer compared to our healthy women in our office. If so, perhaps a non-invasive screening test confirming the presence of this organism in the vaginal microflora would allow for subsequent evaluation of these women for earlier detection of endometrial cancer,” said Etkin-Kramer, before adding “anything that will help prevent a cancer or detect a cancer at its earliest, most treatable stage is definitely a plus.”

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SEOUL — Cosmax, a cosmetics original development manufacturing company in South Korea, has developed an anti-aging cosmetics material called “Strain CX” using microbiome, the genetic material of all the microbes that live on and inside the human body. Strain CX is a composite of microbes with anti-aging characteristics found in the skin of young women.

In the cosmetics industry, microbiome specifically refers to a group of microbes which are known to improve the conditions of internal organs and skin. Microbiome has received attention as a material for next-generation skincare cosmetics, but most cosmetics products that utilize microbiome research technology have used intestinal lactobacillus or milk lactobacillus.

Cosmax promised to release a new lineup of cosmetics that would enhance the anti-aging capability of products targeting fall and winter seasonal markets.

“While all other companies were focusing on the balance of microbiome and the relationship between aging and microbes, we thought that we should approach the skin,” Cosmax organic materials lab head Lee dong-geol said. “Our research performance is based on finding out exactly what our customers want after meeting with them several times.”

“Because skin microbiological research is much higher in the level of research analysis than intestinal microbial research, I have spent the last five years just making a platform for analysis,” Lee said, adding his team found the correlation between anti-aging microbes and skin aging and divided them.

Strain CX can greatly enhance moisture activity and collagen activation, he said. Cosmax promised to release a new lineup of cosmetics that would enhance the anti-aging capability of products targeting fall and winter seasonal markets.

Strain CX was first adopted by Dr. Jart+, a cosmetics brand, to release a moisturizing essence. The product has become the top-selling merchandise at Olive Young, a health and beauty drug store, this summer. Dr. Jart+ will release a new lineup of cosmetics featuring a more concentrated dose of Strain CX.

“While the moisture biome concentrates on the moisturization capability of cosmetics, a new lineup featuring the concentrated dose of the anti-aging element, which is the core of the Strain CX, will be released as autumn and winter come,” Lee said.

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