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	<title>Possible Archives - MyMedicPlus</title>
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		<title>Scientists discover possible genetic target for treating endometriosis</title>
		<link>https://www.mymedicplus.com/blog/scientists-discover-possible-genetic-target-for-treating-endometriosis/</link>
		
		<dc:creator><![CDATA[mymedicplus]]></dc:creator>
		<pubDate>Fri, 13 Nov 2020 05:01:26 +0000</pubDate>
				<category><![CDATA[Uncategorized]]></category>
		<category><![CDATA[discover]]></category>
		<category><![CDATA[Endometriosis]]></category>
		<category><![CDATA[genetic]]></category>
		<category><![CDATA[Possible]]></category>
		<category><![CDATA[scientists]]></category>
		<category><![CDATA[Target]]></category>
		<category><![CDATA[Treating]]></category>
		<guid isPermaLink="false">http://www.mymedicplus.com/news/?p=6287</guid>

					<description><![CDATA[<p>The post <a href="https://www.mymedicplus.com/blog/scientists-discover-possible-genetic-target-for-treating-endometriosis/">Scientists discover possible genetic target for treating endometriosis</a> appeared first on <a href="https://www.mymedicplus.com/blog">MyMedicPlus</a>.</p>
]]></description>
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<p>Source &#8211; https://www.sciencedaily.com/</p>
<p id="first" class="lead">Michigan State University researchers have identified a potential genetic target for treating an especially painful and invasive form of endometriosis.</p>
<div id="text">
<p>Their study published in <em>Cell Reports</em>, a scientific journal, could lead to better treatments for women suffering from severe forms of endometriosis, said Mike Wilson, a postdoctoral fellow in the MSU College of Human Medicine. Wilson and Jake Reske, a graduate student in the MSU Genetics and Genome Sciences Program, are first authors of the study.</p>
<p>Their research focused on a type of endometriosis that occurs in women who have a mutation in a gene called ARID1A, which is linked to the more invasive and painful form of the disease. When ARID1A is mutated, so-called &#8220;super-enhancers,&#8221; a part of the DNA that determines the function of cells, run wild, Reske said. This allows the cells that normally line the uterus to form deep implants outside the uterus and cause severe pelvic pain.</p>
<p>&#8220;There haven&#8217;t been many successful nonhormonal therapies for this form of endometriosis that have made it to the bedside yet,&#8221; Reske said.</p>
<p>In laboratory experiments, he and Wilson tested a drug that appeared to target the super-enhancers and stop the spread of endometriosis. Such a drug &#8212; part of a new type of treatment called &#8220;epigenetic therapy&#8221; that controls how genes are expressed &#8212; could be far more effective than current treatments, including surgery, hormone therapy and pain management.</p>
<p>Endometriosis, particularly the kind associated with the ARID1A mutation, can be debilitating for many women, often leading to infertility.</p>
<p>&#8220;It can seriously impact women&#8217;s quality of life and their ability to have a family and work,&#8221; said Ronald Chandler, an assistant professor of obstetrics, gynecology and reproductive biology, who supervised the study. &#8220;It&#8217;s not easy to treat, and it can become resistant to hormone therapy. The most clinically impactful thing we found is that targeting super-enhancers might be a new treatment for this deeply invasive form of the disease.&#8221;</p>
<p>The drug they studied targeted a protein in cells called P300, suppressing the super-enhancers and offsetting the effects of the ARID1A mutation, Wilson said. The same type of treatment could be used to treat other forms on endometriosis, he said.</p>
<p>The researchers already are planning follow-up studies to find other drugs that could target P300, Wilson and Reske said.</p>
<p>The MSU team collaborated with Van Andel Institute researchers, providing them with tissue samples for VAI scientists to analyze with a machine called a next-generation sequencer.</p>
</div>
<p>The post <a href="https://www.mymedicplus.com/blog/scientists-discover-possible-genetic-target-for-treating-endometriosis/">Scientists discover possible genetic target for treating endometriosis</a> appeared first on <a href="https://www.mymedicplus.com/blog">MyMedicPlus</a>.</p>
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		<title>Global Kidney Stones Management Market Revenue To Witness Humongous Elevation By 2026</title>
		<link>https://www.mymedicplus.com/blog/global-kidney-stones-management-market-revenue-to-witness-humongous-elevation-by-2026/</link>
		
		<dc:creator><![CDATA[mymedicplus]]></dc:creator>
		<pubDate>Wed, 07 Oct 2020 06:08:58 +0000</pubDate>
				<category><![CDATA[Uncategorized]]></category>
		<category><![CDATA[COVID-19]]></category>
		<category><![CDATA[Global]]></category>
		<category><![CDATA[Humongous]]></category>
		<category><![CDATA[Kidney Stones]]></category>
		<category><![CDATA[Possible]]></category>
		<category><![CDATA[several trends]]></category>
		<guid isPermaLink="false">http://www.mymedicplus.com/news/?p=5565</guid>

					<description><![CDATA[<p>The post <a href="https://www.mymedicplus.com/blog/global-kidney-stones-management-market-revenue-to-witness-humongous-elevation-by-2026/">Global Kidney Stones Management Market Revenue To Witness Humongous Elevation By 2026</a> appeared first on <a href="https://www.mymedicplus.com/blog">MyMedicPlus</a>.</p>
]]></description>
										<content:encoded><![CDATA[


<p>Source &#8211; https://rejerusalem.com/</p>
<p> </p>
<p>The comprehensive research report titled “<strong>Global Kidney Stones Management Market Revenue To Witness Humongous Elevation By 2026</strong>” by Zion Market Research supports the reader by assisting to accumulate all possible strategies based on valuable insights in order to maintain the correct tempo with the changing dynamics of the market in the present as well as few years down the line.</p>
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</ul>
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<p> </p>
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<p>Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Asia.</p>
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<p>The post <a href="https://www.mymedicplus.com/blog/global-kidney-stones-management-market-revenue-to-witness-humongous-elevation-by-2026/">Global Kidney Stones Management Market Revenue To Witness Humongous Elevation By 2026</a> appeared first on <a href="https://www.mymedicplus.com/blog">MyMedicPlus</a>.</p>
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		<item>
		<title>Botox, No Longer Just Cosmetic but an Aid in Possible Treatment of Endometriosis</title>
		<link>https://www.mymedicplus.com/blog/botox-no-longer-just-cosmetic-but-an-aid-in-possible-treatment-of-endometriosis/</link>
		
		<dc:creator><![CDATA[mymedicplus]]></dc:creator>
		<pubDate>Sat, 27 Jul 2019 12:02:18 +0000</pubDate>
				<category><![CDATA[Uncategorized]]></category>
		<category><![CDATA[Botox]]></category>
		<category><![CDATA[cosmetic]]></category>
		<category><![CDATA[Endometriosis]]></category>
		<category><![CDATA[Possible]]></category>
		<category><![CDATA[tissues]]></category>
		<category><![CDATA[treatment]]></category>
		<guid isPermaLink="false">http://www.mymedicplus.com/news/?p=1081</guid>

					<description><![CDATA[<p>Source: sciencetimes.com Endometriosis is a disorder that causes pain in the pelvic area of women.&#160; This is a condition where [&#8230;]</p>
<p>The post <a href="https://www.mymedicplus.com/blog/botox-no-longer-just-cosmetic-but-an-aid-in-possible-treatment-of-endometriosis/">Botox, No Longer Just Cosmetic but an Aid in Possible Treatment of Endometriosis</a> appeared first on <a href="https://www.mymedicplus.com/blog">MyMedicPlus</a>.</p>
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<p>Source: sciencetimes.com</p>



<p>Endometriosis is a disorder that causes pain in the pelvic area of women.&nbsp; This is a condition where endometrial tissue, which normally lines the inside of the uterus, grows outside the uterus, most commonly affecting the ovaries, fallopian tubes, and the tissue lining the pelvic region.&nbsp; Sometimes, but not very commonly, the endometrial tissue may even spread beyond a woman&#8217;s pelvic organs.&nbsp; Now as the endometrial tissue would normally be stripped off the uterine lining during menstruation, it would do the same with the other organs affected with endometriosis, causing additional bleeding with each menstrual cycle.&nbsp; But because this stripped off tissues are outside the uterus, there is no exit point for them and they become trapped in the body, causing irritation and possibly other complications.</p>



<p>While Botox is more commonly known for helping make the skin smoother and eliminate wrinkles, a recent study says that the severe pain caused by endometriosis may be relieved for months using Botox injections.</p>



<p>In the study, 13 women of ages 21 to 51 with endometriosis for at least two years agreed to have Botox injected into their pelvic floor, specifically in the areas where muscle spasms were observed.&nbsp; These participants have had surgery and hormone treatments in the past to try to address their condition but to minimum success, their pain persisted.&nbsp; All of them also had muscle spasms in their pelvic floor, which supports the pelvic organs.</p>



<p>Out of the 13 women in the study, eight of them reported that they have experienced moderate to severe disability when it comes to how the pain affects their daily activities from simple walking and standing to personal care and sex life.  After four to eight weeks of treatment, all of the 13 women reported that the pain was observably reduced; 11 of them rated the pain after the treatment as mild or completely gone, as the researchers reported in Regional Anesthesia &amp; Pain Medicine.  In seven of these 13 women, the relief lasted from 5 to 11 months, asking them a year after the treatment.  Out of the eight who said that the pain interfered with their daily lives, six have reported that their disability was reduced after the injection.</p>



<p>Barbara Karp, a neurologist at the National Institute of Neurological Disorders and Stroke, says that the women in the study had been able to benefit beyond the relief of pain.  Some of them were even able to resume having sex without feeling pain.  Andrea Rapkin, an obstetrician, and gynecologist at UCLA&#8217;s David Geffen School of Medicine not involved in the research said that Botox may be a promising tool for the treatment of endometriosis, but she also noted that the treatment is expensive and that the study size was very small.  She noted that larger studies, where Botox is compared with placebo, need to be done in order to be able to evaluate the safety and effectiveness of the botulinum toxin treatment.</p>
<p>The post <a href="https://www.mymedicplus.com/blog/botox-no-longer-just-cosmetic-but-an-aid-in-possible-treatment-of-endometriosis/">Botox, No Longer Just Cosmetic but an Aid in Possible Treatment of Endometriosis</a> appeared first on <a href="https://www.mymedicplus.com/blog">MyMedicPlus</a>.</p>
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