{"id":2290,"date":"2019-10-19T07:12:15","date_gmt":"2019-10-19T07:12:15","guid":{"rendered":"http:\/\/www.mymedicplus.com\/news\/?p=2290"},"modified":"2021-03-31T00:06:23","modified_gmt":"2021-03-30T18:36:23","slug":"keto-diets-may-reverse-polycystic-kidney-disease","status":"publish","type":"post","link":"https:\/\/www.mymedicplus.com\/blog\/keto-diets-may-reverse-polycystic-kidney-disease\/","title":{"rendered":"KETO DIETS MAY REVERSE POLYCYSTIC KIDNEY DISEASE"},"content":{"rendered":"\n<p>Source: futurity.org<\/p>\n<p>Hereditary and relatively common, researchers have long thought polycystic kidney disease (PKD) was progressive and irreversible, condemning people with the condition to a long, slow, and often painful decline as fluid filled cysts develop in the kidneys, grow, and eventually rob the organs of their function.<\/p>\n<p>Once their kidneys fail, PKD patients often require dialysis several times a week or must undergo a kidney transplant. To make matters worse, a host of other PKD-related conditions and complications add to the patients\u2019 health burden, including high blood pressure, vascular problems, and cysts in the liver. And that doesn\u2019t take into account the medical costs and the reduced quality of life.<\/p>\n<p>Progress toward finding a cure has been sluggish, with only one drug proven to slow\u2014but not stop\u2014the progression of PKD. But now, a solution may be no farther than the end of your fork.<\/p>\n<p>\u201cIt\u2019s surprisingly effective\u2014much more effective than any drug treatment that we\u2019ve tested,\u201d says Thomas Weimbs, a biochemist at the University of California, Santa Barbara, whose work focuses primarily on the molecular mechanisms underlying polycystic kidney disease and related renal diseases.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.mymedicplus.com\/blog\/keto-diets-may-reverse-polycystic-kidney-disease\/#KETOSIS_TO_FIGHT_POLYCYSTIC_KIDNEY_DISEASE\" >KETOSIS TO FIGHT POLYCYSTIC KIDNEY DISEASE<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.mymedicplus.com\/blog\/keto-diets-may-reverse-polycystic-kidney-disease\/#EATING_KETONES\" >EATING KETONES<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.mymedicplus.com\/blog\/keto-diets-may-reverse-polycystic-kidney-disease\/#KETONE_SUPPLEMENT\" >KETONE SUPPLEMENT<\/a><\/li><\/ul><\/nav><\/div>\n<h3><span class=\"ez-toc-section\" id=\"KETOSIS_TO_FIGHT_POLYCYSTIC_KIDNEY_DISEASE\"><\/span>KETOSIS TO FIGHT POLYCYSTIC KIDNEY DISEASE<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>In previous studies, the research team found that reducing food intake in mouse models slowed the growth of polycystic kidneys; but at the time, they did not know why. In the new paper, the scientists identified the specific metabolic process responsible for slowing the progress of the disease.<\/p>\n<p>The best part? It\u2019s a process many of us already know well.<\/p>\n<p>\u201cThere\u2019s a way of avoiding the development of the cysts through dietary interventions that lead to ketosis,\u201d Weimbs says.<\/p>\n<p>You read that right: Ketosis, the underlying metabolic state of popular diets such as the\u00a0ketogenic diet, and, to a lesser extent, time-restricted feeding (a form of intermittent fasting), has been shown in the Weimbs group\u2019s studies to stall and even reverse PKD.<\/p>\n<p>\u201cThe cysts appear to be largely glucose-dependent,\u201d Weimbs explains. In people with the predisposition toward PKD, the continuous supply of sugar in the high-carbohydrate, high-sugar diets of modern culture serve to feed the growth and development of the fluid-filled sacs.<\/p>\n<p>\u201cKetosis is a natural response to fasting,\u201d Weimbs says. \u201cWhen we fast, our carbohydrate reserves are very quickly used up. In order to not die, our bodies switch over to a different energy source and that comes from our fat reserves.\u201d<\/p>\n<p>The body, he continues, breaks down the fat reserves into fatty acids and ketones which then take the place of glucose in providing energy to the body. The researchers found that the presence of ketones in the blood stream in particular inhibits the growth of the kidney cysts. And with a steady supply, ketones actually acted to reverse the condition in their animal studies.<\/p>\n<p>The problem with typical Western diets is that we almost never go into ketosis: we eat high-carb, high-sugar foods almost continuously throughout the day, securing for ourselves a continuous supply of glucose. In the\u00a0ketogenic diet, the body\u2019s typical \u201cgo-to\u201d source of energy\u2014glucose\u2014is taken away as ketogenic dieters focus on non-carbohydrate foods, eventually forcing their bodies to mimic the fasting response. Time-restricted feeders, meanwhile, reach that state by limiting the window of time they eat to a small part of the day, leaving the remaining 16-20 hours of their day for the body to use up the carbs and sugars and switch over into ketosis.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"EATING_KETONES\"><\/span>EATING KETONES<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Ketones are actually a class of three different naturally occurring molecules, says Weimbs. Of particular interest and effectiveness is one called BHB (beta hydroxybutyrate), which has been shown \u201cto affect numerous signaling pathways that are implicated in PKD,\u201d according to the study. The team found that by just feeding that ketone to rats with PKD, they were able to create the beneficial effects of ketosis, no special diet restriction needed.<\/p>\n<p>\u201cWhich makes this really amazing,\u201d Weimbs says. \u201cOn top of a normal high-carb diet, which they can eat all day long, if we give them BHB, they\u2019re fine.\u201d After five weeks of treatment with BHB in the drinking water, rat polycystic kidneys were \u201cnearly indistinguishable\u201d from normal ones.<\/p>\n<p>In fact, the result surprised the researchers so much they thought they\u2019d made a mistake. \u201cI was so surprised by the effect of BHB treatment that I had to go and double-check all the genotypes of the animals to make sure they had PKD to start with,\u201d says lead author Jacob Torres, a postdoctoral researcher. \u201cThe effect was really unlike anything I had encountered before.<\/p>\n<p>\u201cThe impact of this research has huge implications on the field of PKD,\u201d Torres continues. It provides a framework, he says, for understanding the pathology of PKD from a metabolic viewpoint and adds another disease to the list that a ketogenic diet can treat.<\/p>\n<p>\u201cOur discovery also has implications for understanding cellular metabolism at a fundamental level as we learn more about what has gone wrong in our disease models. I am really looking forward to the future of research in this field as we explore this new space and uncover even more about what is really going on in PKD.\u201d<\/p>\n<h3><span class=\"ez-toc-section\" id=\"KETONE_SUPPLEMENT\"><\/span>KETONE SUPPLEMENT<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>It\u2019s quite possible to reach ketosis just by avoiding carbs or by fasting for a period of time. \u201cIt\u2019s a very natural way to have your own body produce BHB,\u201d Weimbs says. \u201cSo something like a time-restricted diet is feasible.\u201d<\/p>\n<p>But the key to success with diet-related issues is consistency. Ask virtually any dieter and they\u2019ll tell you that staying on track is the difficult part.<\/p>\n<p>For those with polycystic kidneys who could use an assist with ketosis, whether or not they need to lose weight or wish to change their diets, the Weimbs lab is developing a dietary supplement to add BHB to their regular intake. This patent-pending nutritional supplement would be similar to commercially available ketone products being offered as energy boosters, but formulated specifically for supporting kidney health.<\/p>\n<p>\u201cWe want to make sure we don\u2019t put anything harmful into the bodies of people with potentially compromised kidney function,\u201d Weimbs says. \u201cAnd some of the ketone products already out there are high in potassium and other ingredients that could be detrimental.\u201d<\/p>\n<p>In addition, the supplement in development is combined with another nutrient the researchers have recently shown to inhibit cyst formation in PKD by a completely different mechanism from BHB, thereby approaching the problem from two directions. While not a drug\u2014and therefore less expensive and essentially free of serious side effects\u2014the supplement is nevertheless intended for use by those under medical supervision. Members of the Weimbs team are planning to conduct a clinical trial to test their supplement mixture in people with PKD. Assuming all goes well, they are planning to launch a company to make it available.<\/p>\n<p>\u201cWe\u2019re really excited that we can actually provide a supplement that potentially could help many more people than dietary intervention alone,\u201d Weimbs says.<\/p>\n\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":2291,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[43],"tags":[2110,139,835,1617,222],"class_list":["post-2290","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-weight-loss-gain","tag-pkd","tag-keto-diet","tag-ketogenic-diet","tag-kidney-disease","tag-researchers"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>KETO DIETS MAY REVERSE POLYCYSTIC KIDNEY DISEASE - MyMedicPlus<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mymedicplus.com\/blog\/keto-diets-may-reverse-polycystic-kidney-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"KETO DIETS MAY REVERSE POLYCYSTIC KIDNEY DISEASE - 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