{"id":3696,"date":"2019-12-28T06:18:46","date_gmt":"2019-12-28T06:18:46","guid":{"rendered":"http:\/\/www.mymedicplus.com\/news\/?p=3696"},"modified":"2021-03-31T00:54:49","modified_gmt":"2021-03-30T19:24:49","slug":"study-identifies-factors-of-microbiome-composition-in-endometrial-cancer","status":"publish","type":"post","link":"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/","title":{"rendered":"Study Identifies Factors of Microbiome Composition in Endometrial Cancer"},"content":{"rendered":"\n<p>Source: cancernetwork.com<\/p>\n<p>Researchers from the Mayo Clinic have identified a microbiome signature associated with endometrial cancer, according to a study published in\u00a0Scientific Reports.<sup>1<\/sup><\/p>\n<section class=\"block block-dfp block-dfp-sky-1-160-600\">\n<div id=\"dfp-ad-sky_1_160_600-wrapper\" class=\"dfp-tag-wrapper\">\u00a0<\/div>\n<\/section>\n<p>The signature is in part driven by postmenopausal status, along with additional known risk factors for endometrial cancer such as obesity and high vaginal pH (&gt;4.5), which together significantly modify the composition of the reproductive tract biome and leads to an increased diversity. Previous studies have demonstrated that healthy vaginal microbiota is most commonly low in diversity and dominated by\u00a0Lactobacillispecies.<\/p>\n<p>\u201cOf the 17 taxa we found enriched in (endometrial cancer) patients, 8 were also enriched by postmenopause,\u201d said the researchers. \u201cBecause postmenopausal status is a main risk factor for endometrial cancer, this system can be thought of as an ecological succession towards a disease state.\u201d<\/p>\n<p>The researchers collected microbiome samples from 148 women undergoing a hysterectomy for either endometrial cancer (n = 66) or other benign uterine conditions (n = 75). The samples were analyzed for diversity across multiple parameters identified as known risks for endometrial cancer. In the lower reproductive tract, both \u03b1- and \u03b2-diversity were associated with patient menopause status (<em>P\u00a0<\/em>= 0.002 and\u00a0<em>P\u00a0<\/em>= 0.007, respectively). In the uterus, the microbiome \u03b1-diversity reached significance (<em>P\u00a0<\/em>= 0.024), while \u03b2-diversity did not (<em>P\u00a0<\/em>= 0.221).<\/p>\n<p>\u201cAll parameters analyzed (menopause status, BMI, and vaginal pH) showed a significant impact on the microbiome composition, with postmenopause, obesity, and high vaginal pH significantly increasing the microbiome diversity,\u201d noted the researchers. \u201cOf note was the marked enrichment of\u00a0Anaerococcus, Peptoniphilus<em>,\u00a0<\/em>andPorphyromonas\u00a0species.\u201d<\/p>\n<p>The analysis identified\u00a0<em>P. somerae<\/em>\u00a0as the microbe with the strongest association with endometrial cancer (<em>P\u00a0<\/em>&lt; 0.001), which was present in all patients with type II disease and in 57% of those with hyperplasia.<\/p>\n<p>\u201cWe know other cancers (cervical, gastric cancers) are associated with certain infections (HPV and\u00a0<em>H. Pylori<\/em>, respectively,) so it is intriguing to think that there may be micro-organisms associated with the development of other cancers such as endometrial cancer,\u201d\u00a0commented Elizabeth Etkin-Kramer, MD, FACOG,\u00a0assistant professor of gynecology at Florida International University, Herbert Wertheim School of Medicine, who was not involved in the study.<\/p>\n<p>In addition to the small sample size and lack of diversification of those samples, a noted limitation of the study was the poor overall health of the patients without endometrial cancer.\u00a0<\/p>\n<p>\u201cThese hysterectomy patients came to Mayo Clinic due to abnormal bleeding, pain, or some combination of these,\u201d wrote the researchers. \u201cThese were not healthy women.\u201d<\/p>\n<p>Still, the suggested association of a specific microbiome signature for endometrial cancer is enough to warrant further research \u2013 with the long-term goal of possibly developing a screening test for the disease.<\/p>\n<p>\u201cIf the micriobiome does play a role in endometrial cancer, beyond being a marker for it, this could have important implications for endometrial cancer prevention,\u201d said Maria Walther-Antonio, PhD, of the Miocrobiome Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, in a press release.<sup>2<\/sup><\/p>\n<p>\u201cWe need larger studies to further confirm an association of certain microorganisms in women with endometrial cancer compared to our healthy women in our office. If so, perhaps a non-invasive screening test confirming the presence of this organism in the vaginal microflora would allow for subsequent evaluation of these women for earlier detection of endometrial cancer,\u201d said Etkin-Kramer, before adding \u201canything that will help prevent a cancer or detect a cancer at its earliest, most treatable stage is definitely a plus.\u201d<\/p>\n\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":3697,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[311,389,140,1715,222],"class_list":["post-3696","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-cancer","tag-endometriosis","tag-healthy","tag-microbiome","tag-researchers"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Study Identifies Factors of Microbiome Composition in Endometrial Cancer - MyMedicPlus<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study Identifies Factors of Microbiome Composition in Endometrial Cancer - MyMedicPlus\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"MyMedicPlus\" \/>\n<meta property=\"article:published_time\" content=\"2019-12-28T06:18:46+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-03-30T19:24:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.mymedicplus.com\/blog\/wp-content\/uploads\/2019\/12\/endometrial-cancer-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"225\" \/>\n\t<meta property=\"og:image:height\" content=\"224\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"mymedicplus\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"mymedicplus\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/\"},\"author\":{\"name\":\"mymedicplus\",\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/#\/schema\/person\/064cee11e5bd38b19d197d3f9491488f\"},\"headline\":\"Study Identifies Factors of Microbiome Composition in Endometrial Cancer\",\"datePublished\":\"2019-12-28T06:18:46+00:00\",\"dateModified\":\"2021-03-30T19:24:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/\"},\"wordCount\":561,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.mymedicplus.com\/blog\/wp-content\/uploads\/2019\/12\/endometrial-cancer-1.jpg\",\"keywords\":[\"cancer\",\"Endometriosis\",\"healthy\",\"microbiome\",\"Researchers\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/\",\"url\":\"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/\",\"name\":\"Study Identifies Factors of Microbiome Composition in Endometrial Cancer - MyMedicPlus\",\"isPartOf\":{\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.mymedicplus.com\/blog\/wp-content\/uploads\/2019\/12\/endometrial-cancer-1.jpg\",\"datePublished\":\"2019-12-28T06:18:46+00:00\",\"dateModified\":\"2021-03-30T19:24:49+00:00\",\"author\":{\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/#\/schema\/person\/064cee11e5bd38b19d197d3f9491488f\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/#primaryimage\",\"url\":\"https:\/\/www.mymedicplus.com\/blog\/wp-content\/uploads\/2019\/12\/endometrial-cancer-1.jpg\",\"contentUrl\":\"https:\/\/www.mymedicplus.com\/blog\/wp-content\/uploads\/2019\/12\/endometrial-cancer-1.jpg\",\"width\":225,\"height\":224},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.mymedicplus.com\/blog\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Study Identifies Factors of Microbiome Composition in Endometrial Cancer\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/#website\",\"url\":\"https:\/\/www.mymedicplus.com\/blog\/\",\"name\":\"MyMedicPlus\",\"description\":\"One Blog Daily For Health And Fitness\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.mymedicplus.com\/blog\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/#\/schema\/person\/064cee11e5bd38b19d197d3f9491488f\",\"name\":\"mymedicplus\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.mymedicplus.com\/blog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/47c4b479693017661bd50b83eee2fef50fdbfdcf398ed4b8f69e9f841bd98fc2?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/47c4b479693017661bd50b83eee2fef50fdbfdcf398ed4b8f69e9f841bd98fc2?s=96&d=mm&r=g\",\"caption\":\"mymedicplus\"},\"url\":\"https:\/\/www.mymedicplus.com\/blog\/author\/mymedicplus\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Study Identifies Factors of Microbiome Composition in Endometrial Cancer - MyMedicPlus","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/","og_locale":"en_US","og_type":"article","og_title":"Study Identifies Factors of Microbiome Composition in Endometrial Cancer - MyMedicPlus","og_url":"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/","og_site_name":"MyMedicPlus","article_published_time":"2019-12-28T06:18:46+00:00","article_modified_time":"2021-03-30T19:24:49+00:00","og_image":[{"width":225,"height":224,"url":"https:\/\/www.mymedicplus.com\/blog\/wp-content\/uploads\/2019\/12\/endometrial-cancer-1.jpg","type":"image\/jpeg"}],"author":"mymedicplus","twitter_card":"summary_large_image","twitter_misc":{"Written by":"mymedicplus","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/#article","isPartOf":{"@id":"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/"},"author":{"name":"mymedicplus","@id":"https:\/\/www.mymedicplus.com\/blog\/#\/schema\/person\/064cee11e5bd38b19d197d3f9491488f"},"headline":"Study Identifies Factors of Microbiome Composition in Endometrial Cancer","datePublished":"2019-12-28T06:18:46+00:00","dateModified":"2021-03-30T19:24:49+00:00","mainEntityOfPage":{"@id":"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/"},"wordCount":561,"commentCount":0,"image":{"@id":"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/www.mymedicplus.com\/blog\/wp-content\/uploads\/2019\/12\/endometrial-cancer-1.jpg","keywords":["cancer","Endometriosis","healthy","microbiome","Researchers"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/","url":"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/","name":"Study Identifies Factors of Microbiome Composition in Endometrial Cancer - MyMedicPlus","isPartOf":{"@id":"https:\/\/www.mymedicplus.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/#primaryimage"},"image":{"@id":"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/www.mymedicplus.com\/blog\/wp-content\/uploads\/2019\/12\/endometrial-cancer-1.jpg","datePublished":"2019-12-28T06:18:46+00:00","dateModified":"2021-03-30T19:24:49+00:00","author":{"@id":"https:\/\/www.mymedicplus.com\/blog\/#\/schema\/person\/064cee11e5bd38b19d197d3f9491488f"},"breadcrumb":{"@id":"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/#primaryimage","url":"https:\/\/www.mymedicplus.com\/blog\/wp-content\/uploads\/2019\/12\/endometrial-cancer-1.jpg","contentUrl":"https:\/\/www.mymedicplus.com\/blog\/wp-content\/uploads\/2019\/12\/endometrial-cancer-1.jpg","width":225,"height":224},{"@type":"BreadcrumbList","@id":"https:\/\/www.mymedicplus.com\/blog\/study-identifies-factors-of-microbiome-composition-in-endometrial-cancer\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.mymedicplus.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Study Identifies Factors of Microbiome Composition in Endometrial Cancer"}]},{"@type":"WebSite","@id":"https:\/\/www.mymedicplus.com\/blog\/#website","url":"https:\/\/www.mymedicplus.com\/blog\/","name":"MyMedicPlus","description":"One Blog Daily For Health And Fitness","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.mymedicplus.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.mymedicplus.com\/blog\/#\/schema\/person\/064cee11e5bd38b19d197d3f9491488f","name":"mymedicplus","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.mymedicplus.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/47c4b479693017661bd50b83eee2fef50fdbfdcf398ed4b8f69e9f841bd98fc2?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/47c4b479693017661bd50b83eee2fef50fdbfdcf398ed4b8f69e9f841bd98fc2?s=96&d=mm&r=g","caption":"mymedicplus"},"url":"https:\/\/www.mymedicplus.com\/blog\/author\/mymedicplus\/"}]}},"_links":{"self":[{"href":"https:\/\/www.mymedicplus.com\/blog\/wp-json\/wp\/v2\/posts\/3696","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.mymedicplus.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mymedicplus.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mymedicplus.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mymedicplus.com\/blog\/wp-json\/wp\/v2\/comments?post=3696"}],"version-history":[{"count":1,"href":"https:\/\/www.mymedicplus.com\/blog\/wp-json\/wp\/v2\/posts\/3696\/revisions"}],"predecessor-version":[{"id":3698,"href":"https:\/\/www.mymedicplus.com\/blog\/wp-json\/wp\/v2\/posts\/3696\/revisions\/3698"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.mymedicplus.com\/blog\/wp-json\/wp\/v2\/media\/3697"}],"wp:attachment":[{"href":"https:\/\/www.mymedicplus.com\/blog\/wp-json\/wp\/v2\/media?parent=3696"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mymedicplus.com\/blog\/wp-json\/wp\/v2\/categories?post=3696"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mymedicplus.com\/blog\/wp-json\/wp\/v2\/tags?post=3696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}