{"id":4453,"date":"2020-02-06T07:10:55","date_gmt":"2020-02-06T07:10:55","guid":{"rendered":"http:\/\/www.mymedicplus.com\/news\/?p=4453"},"modified":"2021-03-31T00:40:23","modified_gmt":"2021-03-30T19:10:23","slug":"another-bites-the-dust-h-i-v-vaccine-shut-down-as-it-fails-trial-disappointing-researchers","status":"publish","type":"post","link":"https:\/\/www.mymedicplus.com\/blog\/another-bites-the-dust-h-i-v-vaccine-shut-down-as-it-fails-trial-disappointing-researchers\/","title":{"rendered":"Another bites the dust: H.I.V. vaccine shut down as it fails trial, disappointing researchers"},"content":{"rendered":"\n

Source: irstpost.com<\/p>\n

In another setback in the long quest to prevent HIV infection, a trial in South Africa has been shut down because an experimental vaccine was not working, federal health officials announced Monday.<\/p>\n

The trial, which began in 2016, followed one in Thailand that ended in 2009. That vaccine offered only modest protection against infection. Experts argued over how much, but the vaccine was no more than 30% protective.<\/p>\n

Nonetheless, it was the only vaccine that had appeared to work at all.<\/p>\n

\u201cWe hoped this vaccine candidate would work \u2014 regrettably, it does not,\u201d said Dr Anthony S. Fauci, director of the National Institute for Allergy and Infectious Diseases, which conducted the trial.<\/p>\n

A vaccine against HIV, the virus that causes AIDS, is sorely needed. Even now, nearly 40 years after the start of the epidemic, 1.7 million people are newly infected each year \u2014 most of them in Africa, especially southern Africa, according to UNAIDS, the United Nations\u2019 AIDS-fighting agency.<\/p>\n

The trial \u2014 known as HVTN 702 but nicknamed Uhambo, which means \u201cjourney\u201d in Zulu \u2014 included 5,407 young adult men and women in South Africa.<\/p>\n

\n
\u00a0<\/div>\n<\/div>\n

Last month, a safety-monitoring panel looked at early results and found there were 123 infections among participants who got a placebo injection and 129 among those who got the vaccine.<\/p>\n

That clearly indicated that the vaccine was not protective but did not mean it was making participants more vulnerable to HIV, scientists said. A difference of just six infections in so large a pool of participants could have been due to chance.<\/p>\n

The Uhambo vaccine had to be significantly changed from the one tested in Thailand because South Africa has a different dominant strain of HIV.<\/p>\n

The vaccine used canarypox, a bird virus that can infect human cells but cannot multiply in them, to deliver into the body a protein found on the outer envelope of HIV The immune system learns to recognize the protein and to make protective antibodies to it.<\/p>\n

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