{"id":4606,"date":"2020-02-14T06:47:29","date_gmt":"2020-02-14T06:47:29","guid":{"rendered":"http:\/\/www.mymedicplus.com\/news\/?p=4606"},"modified":"2020-02-14T06:47:29","modified_gmt":"2020-02-14T06:47:29","slug":"sanofis-sunny-forecast-for-dupixent-and-its-aging-diabetes-drugs-just-might-be-achievable-analyst","status":"publish","type":"post","link":"https:\/\/www.mymedicplus.com\/blog\/sanofis-sunny-forecast-for-dupixent-and-its-aging-diabetes-drugs-just-might-be-achievable-analyst\/","title":{"rendered":"Sanofi\u2019s sunny forecast for Dupixent and its aging diabetes drugs just might be achievable: analyst"},"content":{"rendered":"\n

Source:fiercepharma.com<\/p>\n

Ever since he took over as CEO of Sanofi late last year, Paul Hudson has been promising skeptical investors that the company\u2019s hot immunology drug Dupixent could eventually hit \u20ac10 billion in annual sales. That would go a long way towards making up for Sanofi\u2019s flagging diabetes drugs, but Wall Street analysts aren\u2019t necessarily convinced it\u2019s achievable.<\/p>\n

\u00a0<\/div>\n

Now, one influential Wall Street firm\u00a0is making the bull case for Sanofi, declaring not only that the company\u2019s Dupixent forecast is achievable, but that the diabetes situation isn\u2019t as bad as it looks.<\/p>\n

Geoffrey Porges and his colleagues at SVBLeerink peg sales of Dupixent at \u20ac3.5 billion this year and \u20ac9.1 billion in 2026. That long-term forecast is 10% to 15% higher than the consensus estimate.<\/p>\n

\n
\u00a0<\/div>\n<\/div>\n

It’s built on expectations for new Dupixent approvals. The med is currently approved to treat atopic dermatitis, sinusitis and asthma, but SVBLeerink\u2019s analysts believe it has a good chance of success in a half-dozen or so other diseases, including esophagitis.<\/p>\n

The reason for their optimism? Anecdotal reports published in the scientific literature suggest that Dupixent works in several diseases that are not yet included in the product\u2019s label, they said. That bodes well for \u201cmultiple label expansion opportunities,\u201d they wrote in a report to investors.<\/p>\n

Several trials are underway and \u201cadoption should be relatively high, provided Dupixent shows efficacy consistent with the anecdotal reports. At this stage the biology of these diseases \u2026 suggests that there is a relatively high probability of a positive outcome from these trials,\u201d they said.<\/p>\n

During Sanofi\u2019s fourth-quarter earnings call last week, Hudson said that with Dupixent, \u201cI think we have a realistic expectation to be the leading biologic in the dermatologist’s office. Likewise in allergists.\u201d As for the future, he added \u201cthe foundation stones are very, very strong for what we are doing with Dupixent across multiple geographies, multiple indications and multiple specialty groups.\u201d<\/p>\n

Dupixent\u2019s strong 2019 growth\u2014sales jumped 151% to \u20ac2.1 billion for the year\u2014came amid declining sales of Sanofi\u2019s diabetes products. Revenues for the diabetes franchise fell 8% to \u20ac5.1 billion.<\/p>\n

In fact, Sanofi\u2019s diabetes sales grew reliably until 2015, but they’ve been falling every year since, SVBLeerink pointed out in a second report to investors. Much of the decline was attributed to biosimilar competition from Eli Lilly, which has cut into Sanofi\u2019s dominance in the long-acting insulin market. Sales of Sanofi\u2019s Lantus have been cut in half by Lilly\u2019s rival Basaglar.<\/p>\n

Still, SVBLeerink predicts that the decline of Sanofi\u2019s diabetes business will stabilize starting in 2021, thanks to Toujeo, its ultra-long-lasting insulin product. Sales of Toujeo grew 3% to \u20ac883 million last year. The analysts expect sales of the product will increase to \u20ac1.2 billion in 2023.<\/p>\n

\u201cOur estimates and confidence in the [diabetes] business unit\u2019s stabilization are based on flattening market share loss, moderating price declines, and ex-US revenue growth,\u201d they wrote.<\/p>\n

Earlier this week, Sanofi followed up on its fourth-quarter report by shaking up its top management ranks, shrinking the executive committee from 14 to 10 people. The change included separating the roles of chief medical officer and chief digital officer, both of which were held by Ameet Nathwani. He was among the executives who headed for the exits.<\/p>\n

Hudson said during the fourth-quarter conference call that boosting the role of chief digital officer would help the company \u201cimprove our user experience and data science management internally.\u201d He admitted Sanofi has been slow to embrace technologies like AI in drug discovery and development.<\/p>\n

Whether all these changes will help Sanofi reach its lofty goals for Dupixent remains to be seen. There are plenty of obstacles, including brewing\u00a0competition\u00a0from more than 20 immunology drugs in the pipeline. Nevertheless, SVBLeerink said, \u201cDupixent is the brightest spot in an otherwise fairly lackluster pipeline and portfolio.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":4607,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32],"tags":[1058,1204,1050,3061],"class_list":["post-4606","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-diabetes","tag-diabetes","tag-drugs","tag-forecast","tag-sanofis-sunny"],"yoast_head":"\nSanofi\u2019s sunny forecast for Dupixent and its aging diabetes drugs just might be achievable: analyst - MyMedicPlus<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mymedicplus.com\/blog\/sanofis-sunny-forecast-for-dupixent-and-its-aging-diabetes-drugs-just-might-be-achievable-analyst\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sanofi\u2019s sunny forecast for Dupixent and its aging diabetes drugs just might be achievable: analyst - 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