source:- drugtopics<\/p>\n
Individuals with pre-existing conditions, such as type 2 diabetes, have a demonstrated higher risk for developing more severe cases of coronavirus disease 2019 (COVID-19) infection, leading to higher morbidity and mortality. A new study sheds light on improving outcomes for patients with type 2 diabetes who are infected with the virus, suggesting that a focus on blood glucose (BG) control may be key.\u00a0<\/p>\n For the study, which was published in\u00a0Cell Metabolism<\/em>, investigators performed a retrospective, multi-centered analysis of 7337 cases of COVID-19 in Hubei Province, China, among which 952 had pre-existing type 2 diabetes.<\/p>\n The results showed that patients with type 2 diabetes required more medical interventions and had a significantly higher mortality (7.8% versus 2.7%; adjusted hazard ratio [HR], 1.49) and multiple organ injury than those without diabetes. Patients with diabetes registered a higher need for antibiotics, antifungal drugs, systemic corticosteroids, immunoglobin, anti-hypertensive drugs, and even vasoactive drugs, according to the data. Oxygen inhalation, noninvasive ventilation, and invasive ventilation was also more common in those with type 2 diabetes compared with those without.<\/p>\n However, the study showed that well-controlled BG (glycemic variability within 3.9 to 10.0 mmol\/L) was associated with markedly lower mortality compared with individuals with poorly controlled BG (upper limit of glycemic variability exceeding 10.0 mmol\/L) (adjusted HR, 0.14) during hospitalization.<\/p>\n Patients from the well-controlled BR group also received less medical interventions, such as supplemental oxygen and\/or ventilation, and had significantly lower incidences of lymphopenia, lower rates of increase counts of leukocyte and neutrophil, and elevated serum CRP and procalcitonin.<\/p>\n \u201cWe were surprised to see such favorable outcomes in well-controlled blood glucose group among patients with COVID-19 and pre-existing type 2 diabetes,\u201d senior author Hongliang Li of Renmin Hospital of Wuhan University, said in a press release. \u201cConsidering that people with diabetes had much higher risk for death and various complications, and there are no specific drugs for COVID-19, our findings indicate that controlling blood glucose well may act as an effective auxiliary approach to improve the prognosis of patients with COVID-19 and pre-existing diabetes.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":5169,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[40],"tags":[1967,3204,1058,1963,184],"class_list":["post-5168","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-heart-care","tag-blood-sugar","tag-covid-19","tag-diabetes","tag-type-2-diabetes","tag-virus"],"yoast_head":"\n