Source – https:\/\/www.healio.com\/<\/p>\n
Among patients with HIV who are in care, the rate of hospitalization for any cause declined substantially during a recent 10-year period, according to study findings published in\u00a0The<\/em>\u00a0Journal of Infectious Diseases<\/em>.<\/p>\n Hospitalization rates declined despite the potential effects of aging,\u00a0comorbidities\u00a0and cumulative exposure to HIV and antiretrovirals, researchers said.<\/p>\n In their study,\u00a0Thibaut Davy-Mendez, PhD<\/strong>,\u00a0<\/strong>a post-doctoral fellow in the department of psychiatry and behavioral sciences at the University of California, San Francisco,\u00a0<\/strong>Stephen A. Berry, MD, PhD<\/strong>,\u00a0<\/strong>associate professor of medicine at Johns Hopkins University School of Medicine,\u00a0<\/strong>and colleagues examined trends in all-cause and cause-specific hospitalization rates between 2005 and 2015 to assess the possible impact of ART improvements, aging and comorbidities on hospitalizations among people living with HIV (PLWH) who are receiving care.<\/p>\n The study included PLWH receiving care in six clinical cohorts in the United States and Canada.<\/p>\n Among the 28,057 patients ultimately included in the study, the median CD4 increased from 389 to 580 cells\/\u00b5L, and the proportion of patients who were virologically suppressed rose from 55% to 85%.<\/p>\n According to the researchers, the unadjusted all-cause hospitalization rate decreased from 22.3 per 100 person years in 2005 (95% CI, 20.6-24.1) to 13 per 100 person years in 2015 (95% CI, 12.2-14). Additionally, unadjusted rates decreased for almost all diagnostic categories, whereas adjusted rates decreased for all-cause, cardiovascular and AIDS-defining conditions. They increased for non-AIDS-defining infection and were stable for most other categories.<\/p>\n According to Davy-Mendez and Berry, previous data showed similar results. Data from the 2000s revealed a decrease in hospitalization rates among PLWH but slight increases in cardiovascular and kidney disease hospitalizations. Additionally, more recent studies in North Carolina and Italy found a continued decrease in hospitalization rates among people with HIV through 2016.<\/p>\n \u201cOur study is the most recent work reporting hospitalization trends across a large number of people living with HIV in the United States and Canada,\u201d they said.\u00a0<\/strong>\u201c<\/strong>Based on previous studies, we expected that non-AIDS-defining infections would make up a substantial percentage of hospitalization reasons. However, we did not expect to see a small increase in the adjusted hospitalization rate [of] non-AIDS-defining infections.\u201d<\/p>\n They said this finding will require\u00a0further investigation to understand\u00a0the drivers of these infections and possible ways to prevent them.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":6316,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[52,4006,4341,4342,55,4340],"class_list":["post-6315","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aids-hiv","tag-hiv","tag-hospitalized","tag-less","tag-past","tag-patients","tag-substantially"],"yoast_head":"\n